Preheat your oven to 350°F. Lightly spray a 9x13-inch baking dish with nonstick cooking spray.

In a large skillet over medium heat, cook the ground beef until it's fully browned and no longer pink. Drain off any excess fat.

Stir in the ketchup, water, brown sugar, Worcestershire sauce, mustard, garlic powder, onion powder, and salt. Let the mixture simmer for about 5 minutes, then remove from heat.

Transfer the meat mixture to a large bowl. Add the quartered biscuit pieces and toss gently until everything is well coated.

Pour the biscuit and meat mixture into the prepared baking dish, spreading it into an even layer.

Sprinkle the shredded cheddar cheese evenly over the top.

Bake for 28 to 30 minutes, until the biscuits are golden brown and the casserole is bubbly around the edges.

Remove from the oven and let it cool for a few minutes before serving.